Measuring ¹²⁹ Xe transfer across the blood‐brain barrier using MR spectroscopy

Purpose This study develops a tracer kinetic model of xenon uptake in the human brain to determine transfer rate inhaled hyperpolarized 129 Xe from cerebral blood gray matter that accounts for effects physiology, perfusion and magnetization dynamics. The is expressed using coefficient, which estimates quantity dissolved under exchange with depolarized equilibrium concentration. Theory Methods Time‐resolved MR spectra were acquired three healthy volunteers. Acquired numerically fitted five Lorentzian peaks accordance known spectral peaks. signal dynamics red cells quantified, correction T 1 dependence upon oxygenation was applied. determined ratio developed model. Results For all NMR spectra, data coefficients between 0.1 0.14. Conclusion In this study, validated HP brain.